Patients were divided into four subgroups according to their profiles of tumor cell CTLA-4 expression and CTLA-4+ TIMC density: Group 1 (CTLA-4high tumor cells, densityhigh CTLA-4+ TIMCs), Group 2 (CTLA-4high tumor cells, densitylowCTLA-4+ TIMCs), Group 3 (CTLA-4low tumor cells, densityhighCTLA-4+ TIMCs), and Group 4 (CTLA-4lowtumor cells, densitylowCTLA-4+ TIMCs). The gene discussed is CTLA4; the disease is neoplasm.