In addition, we validated that Sp1 siRNA increased the sensitivity of HepG2-X and H7402-X cells to CDC using CDC analysis, whereas overexpression of C4BPα could abolish the increase (Figure 5F), supporting that Sp1 is involved in the escape of hepatoma cells from complement attack induced by C4BPα. The gene discussed is SP1; the disease is hepatocellular carcinoma.