In this study, we demonstrated that chronic cerebral hypoperfusion from graduated unilateral common carotid occlusion results in an increase in p-Tau levels in the hippocampus and cortex of both aged WT and AD mice; however, ligation had no effect on the expression of Aβ42 in either the hippocampus or cortex of the WT and AD mice. This evidence concerns the gene MAPT and Alzheimer disease.