MAPT and Alzheimer disease: We found that in young adult mice (3-month-old), two months after UCCAO ligation, the level of p-Tau was significantly increased in the hippocampus of AD mice compared with the sham AD (Fig. 1A,B, 40% increase); however, UCCAO ligation induced no change of p-Tau in the hippocampus of WT mice.