In the present study, over-expression of p-Mnk1 was significantly associated with poor overall survival of NSCLC patients and high expression of p-Mnk1 might act as an independent poor prognostic factor for these patients, which was similar to the findings in our previous study on nasopharyngeal carcinoma (NPC) [27]. Here, MKNK1 is linked to non-small cell lung carcinoma.