MKNK1 and metastatic malignant neoplasm in the lymph nodes: Moreover, multivariate Cox's proportional hazard regression analysis indicated that the positive expression of p-Mnk1 could act as an independent poor prognostic biomarker for NSCLC patients (P = 0.035), regardless of lymph node metastasis (LNM) status, clinical stages and pathological grades (P = 0.04, P < 0.001, P = 0.01, respectively) (Table 1).