In addition, patients with an advanced tumor stage or microvascular invasion showed relatively low ASK1 protein levels (Figure 2E, P < 0.0001; and Figure 2F, P < 0.0001) and patients with low ASK1 expression exhibited a much lower overall survival (OS) compared with those with high ASK1 expression (median OS 22 and 47 months, respectively; P = 0.0116; Figure 2G). Here, MAP3K5 is linked to neoplasm.