Although some mechanisms involved in the therapeutic effect of HNF4α on HCC have been comprehended in depth over the past few years [9, 12, 15, 16], it is still of considerable interest to identify new pathways, as HNF4α is a wide-acting transcription factor that regulates numerous downstream targets [36, 37]. The gene discussed is HNF4A; the disease is hepatocellular carcinoma.