On the other hand, activation of intrinsic pro-inflammatory signaling pathways (Jak/Stat, p38 and p44), expression of both general (Il1b, Il6, Tnf and Ccl2) and more psoriasis-related (Il17c, Il23 and Il33) cytokines associated with a strong immune response were leading to a phenotype resembling psoriasiform dermatitis. This evidence concerns the gene IL6 and psoriasis.