At later stages, the basal keratinocytes layer exhibited also DNA Damage signaling with Cdkn2a and Trp53 response but these changes in contrast to those in HF progenitor were associated with the absence of pro-inflammatory cytokines expression, increased proliferation, lack of differentiation and immune response reminiscent of psoriasiform dermatitis. This evidence concerns the gene TP53 and Psoriasiform dermatitis.