In summary, Nbn-deficiency promotes psoriasiform dermatitis during ageing, exhibiting important accumulation of DNA damage in proliferative keratinocytes and induction of Trp53/Cdkn1a and Cdkn2a but lack of pro-inflammatory response via Tnf, Il6 and Il1b. The gene discussed is TNF; the disease is Psoriasiform dermatitis.