MED8 and Leber congenital amaurosis: To validate the transcriptional data obtained from the analysis of the Oncomine database, two tumors [renal cell carcinoma (RCC), lung cancer (LCa)] were selected for protein analysis (IHC) and functional analysis of either MED8 or MED12 respectively on large tissue microarray (TMA) cohorts with available clinical information and cell lines.