While differentially expressed subunits in testicular (n = up to 23) and pancreatic tumors (n = 12) were found with a frequency of 100%; only low frequencies for over- (30% in CDK19, n = 121/404) and underexpression (8% in MED22, n = 23/290) were detected in prostate cancer. This evidence concerns the gene MED22 and Familial prostate cancer.