To validate the transcriptional data obtained from the analysis of the Oncomine database, two tumors [renal cell carcinoma (RCC), lung cancer (LCa)] were selected for protein analysis (IHC) and functional analysis of either MED8 or MED12 respectively on large tissue microarray (TMA) cohorts with available clinical information and cell lines. This evidence concerns the gene MED12 and hereditary clear cell renal cell carcinoma.