Upon closer examination of the individual subunits, for MED8, a subunit of the head module, high overexpression rates in ovarian (71%, n = 586/820), lung (47%, n = 226/483), bladder cancer (100%, n = 109/109) and renal cell carcinoma (20%, 10/50) were found. This evidence concerns the gene MED8 and hereditary clear cell renal cell carcinoma.