RNF180 and gastric cancer: The location of every hypermethylation site in RNF180 gene and distribution of hypermethylation frequency in GC, AG and control groups were shown in Supplementary Table S1, Based on a comparative analysis of relationships between MSC or HSC and GC or AG, we selected 8 CpG sites with which hypermethylation frequencies > 25% among a total 513 individuals—M3(−165), M5(−148), M7(−133), M8(−130), M20(−57), M25(−34), M27(−26) and M30(+5)—to evaluate the risk of AG or GC.