SPHK1 and cancer: The data was deeply mined and results showed that in the 65 pairs of colorectal normal and cancers, PRSS8 was higher and Sphk1 was lower in normal colorectal mucosa, but RPSS8 was significantly reduced (p=1.8×10−5) and Sphk1 was dramatically increased in colorectal cancers (p=9.1×10−28, Figure 3E), exhibiting a strong negative correlation.