PRSS8 and ovarian carcinoma: More importantly, both oncologic and tumor suppressing roles of PRSS8 have been demonstrated in ovarian cancers [12, 13], for instance, one study showed that PRSS8 levels were increased in the serum of ovarian cancer patients [14], and another study showed that PRSS8 expression was decreased in chemoresistant ovarian cancer patients and chemoresistant cell line, and forced overexpression of prostasin in ovarian cancer cells greatly induced cells death [15].