Moreover, the NF-κB inhibitor (IKK2) similarly suppressed lymphoma cell invasiveness and collagenase activity (Figure 6E and 6F), supporting a direct role for OPN-mediated activation of NF-κB in MMP8 regulation, extracellular matrix (ECM) remodeling, and lymphoma cell invasion. The gene discussed is NFKB1; the disease is lymphoma.