IGFBP2 and metastatic malignant neoplasm in the lymph nodes: IGFBP-2 expression combined with cell adhesion protein, β-catenin, is linked with lymph node metastasis in BCs [42] and high levels of IGFBP-2 expression together with loss of PTEN expression are also associated with triple negative (TN) BC and poor survival rates [43].