To minimize potential systemic toxicity, we injected the non-irradiated EGFR-CAR NK-92 cells or oHSV-1 intratumorally at day 10 post-tumor cell implantation and oHSV-1 at day 15 for the group of EGFR-CAR NK-92 combined with oHSV-1. This evidence concerns the gene EGFR and neoplasm.