As shown in (Figure 6C), we found interrupting ATF3 expression in the LM3-wpiTR4 cells reversed the overexpressed TR4-enhanced cisplatin chemo-sensitivity in HCC LM3 cells, suggesting that TR4 might function through altering the ATF3 expression to enhance cisplatin chemo-sensitivity in HCC LM3 cells. This evidence concerns the gene NR2C2 and hepatocellular carcinoma.