AKT1 and neoplasm: Despite the clear evidence showing a prosurvival role of miR-149 in U87 MG and A172 cells (wild-type p53), miR-149 has been reported to be a tumor suppressor, which may be involved in the proliferation and invasion of U251 GM cells (p53 mutant) via blockade of AKT1 signaling and miR-149 inhibit SF126 glioblastoma cells proliferation and migration (p53 loss) [18, 20].