PBK and neoplasm: Our findings are similar to findings in other cancers [19, 30], who showed that the administration of HI-TOPK-032 at a dose of 5 mg/kg bodyweight as an experimental therapy led to a massive reduction in tumor volume, in the meantime, there were no obvious toxicity or significant loss of body weight similar to the vehicle-treated group, through the normal tissues data published recently [31], the data showed that expression of PBK in 32 human organs tissues, is hard to detect in vital organs except for testis and might be a promising molecular target