ANXA2 and neoplasm: Similarly, angiogenesis-related genes, likely to impact neighbouring ECs, were significantly induced, including VEGFA, TGFB1, ANXA2, NRP1, NRP2, MMP2, MMP14, PLAUR, NOS2 and ANGPT2. This was further corroborated by the upstream regulator analysis identifying the HIF1A transcription network to be activated in angiogenic tumours (Suppl.