Similarly, angiogenesis-related genes, likely to impact neighbouring ECs, were significantly induced, including VEGFA, TGFB1, ANXA2, NRP1, NRP2, MMP2, MMP14, PLAUR, NOS2 and ANGPT2. This was further corroborated by the upstream regulator analysis identifying the HIF1A transcription network to be activated in angiogenic tumours (Suppl. This evidence concerns the gene NOS2 and neoplasm.