The most pronounced changes were observed in ECs from angiogenic tumours (635 DEGs for P13 vs.NB), where functional pathway analysis pointed to the induction of cell cycle and proliferation activity, induction of vascular development and angiogenesis (e.g. Mmp14, Col1a1, Tnc, Nos2, Angpt2, Angpl4, Thbs1, Tnfaip2) (Figure 6B, Suppl. This evidence concerns the gene THBS1 and neoplasm.