While some studies reported that ligand-independent and ligand-dependent activation of NOTCH1 or overexpression of NOTCH1 promotes cell cycle progression [40–42], quite a few studies suggested a tumor suppressive role for NOTCH1 given that the overexpression of the intracellular region of Notch1 (ICN) inhibits cell cycle at G1 phase or G2 phase [43–45]. The gene discussed is NOTCH1; the disease is neoplasm.