The ratio of cytoplasm to nuclear increased from 0.89 in normal skin, to 1.82 in SCC and to 5.85 in metastasis (Figure 1C), indicating that down-regulation of IKKα in SCC and hemangioma and delocation of IKKα in SCC and metastasis may be associated with this critical step in tumor progression. The gene discussed is CHUK; the disease is neoplasm.