The ratio of cytoplasm to nuclear increased from 0.89 in normal skin, to 1.82 in SCC and to 5.85 in metastasis (Figure 1C), indicating that down-regulation of IKKα in SCC and hemangioma and delocation of IKKα in SCC and metastasis may be associated with this critical step in tumor progression. This evidence concerns the gene CHUK and hemangioma.