In BCC, we first provide evidence the interplay role of gp130-STAT3 pathway on LGR5, a direct target of HH signaling pathway, is stimulated by IL-6 and other members of the IL-6 family member and a direct link between HH-LGR5 and gp130-STAT3 exist in BCC. The gene discussed is STAT3; the disease is skin basal cell carcinoma.