Results showed that the NIM network underlying cognitive impairment of SAMP8 mice contained 127 nodes and 178 edges with characteristic path length 3.964 (Figure 3a3), and network of APP/PS1 mice contained 67 nodes and 84 edges with characteristic path length 6.533 (Figure 3b3) (supplemental material 2). The gene discussed is APP; the disease is Cognitive impairment.