But it has also been reported that the mechanisms of cognitive impairments in SAMP8 mice may be related with neuronal degeneration [12], inflammatory-amyloid cycle driven by oxidative stress [13], age-related decrease in serum androgen and estrogen levels [14, 15], elevated triggering receptor expressed on myeloid cells 2 (TREM2) [16], increased expression of pro-inflammatory cytokines [17]. The gene discussed is TREM2; the disease is Cognitive impairment.