In this study, indiscriminate cytokine secretion was one of potential mechanism underlying cognitive impairments in APP/PS1 mice and SAMP8 mice, although the direct reason causing AD-like behaviors and pathology of APP/PS1 mice and SAMP8 mice was considered the overexpression of the hAPP encoding gene with Swedish mutation together with the mutant PS1 gene and accelerated aging respectively. The gene discussed is APP; the disease is Alzheimer disease.