MYC and lung carcinoma: To better understand the role of GSK-3α and examine the critical genes affected by GSK-3α in lung cancer, we initially screened a subset of NF-κB target genes such as MYC, WT1, BIRC2, IL-9, HMOX1, and TERT, which were regulated by a pan-GSK-3 inhibitor AR-014418 in pancreatic cancer [30].