CDK19 and osteosarcoma: Furthermore, a recent study using a novel robust and highly efficient genome editing tool, the clustered regularly interspaced short palindromic repeats-Cas9 (CRISPR-Cas9) system, to silence endogenous CDK11 DNA found that CDK11 knockout significantly reduced osteosarcoma cell viability, proliferation, migration, invasion, and induced cell death [99].