BCL2 and plasma cell myeloma: After BDA-366 treatments at concentration of 0.25 and 0.5μM, phosphorylation of BCL2 significantly decreased in both RPMI8226 (Figure 3A–3B) and U266 (Figure 3C–3D) cells, coincident with BDA-366-induced exposure of the BCL2 BH3 domain in the treated myeloma cells (Figure 2B and 2D).