BCL2 BH4 domain also binds to calcineurin, CED-4, HIF-1α, c-Myc, paxillin, Raf-1, Ras and VDAC, promoting tumorigenesis or tumor survival and contributing to both anti-apoptosis and pro-tumorgenesis activities of BCL2 [37]. Here, VDAC1 is linked to neoplasm.