ITPR1 and Miyoshi myopathy: The BCL2 BH4 domain has been shown to directly bind and inhibit inositol 1,4, 5-trisphosphate receptors (IP3R) [28], which serve as the main intracellular Ca2+-release channel of the ER [29], a decoy peptide binding the BH4 domain by blocking the interaction between BCL2 and IP3R induces Ca2+-mediated apoptosis in MM cells [30].