AR and posterior cortical atrophy: This recent finding together with the present data, suggest that in PCa Brachyury can suppress PTEN leading to increased activation of Akt signaling and consequently aberrant transcription of down-stream checkpoint genes, like Bcl-2 and ERG. Aberrant expression of an ETS transcription factor (usually ERG) is also found in response to the activated AR [38], as those promoted by Brachyury overexpression.