Comparing only the control cells (transfected with empty vectors), the metastatic PC3 cells (with endogenous Brachyury expression) demonstrated to be more resistant to docetaxel and cabazitaxel than the primary PCa 22RV1 and the bone metastatic DU145 cells (negative for Brachyury expression) (Supplementary Figure S1B). The gene discussed is TBX1; the disease is posterior cortical atrophy.