For instance, transcript levels of the antisense noncoding RNA in the INK4 locus (ANRIL, alias CDKN2B-AS1) lncRNA, which is encoded on chromosome 9p21 at the strongest genetic susceptibility locus for CAD, are directly correlated with the severity of atherosclerosis [16]. This evidence concerns the gene CDKN2B-AS1 and coronary artery disorder.