CD34 and alkaline phosphatase measurement: First, to investigate the degree to which CML progression is driven by hematopoietic cell population dynamics as opposed to differences in the genetic underpinnings of respective disease stages, we analysed GEO dataset GSE47927, comprising data obtained from CD34+ enriched, flow sorted CML stem and progenitor cell populations from 12 CML patients, of which six CP, four AP, and two BC, versus matching populations from three healthy volunteers (Supplementary Resources and Methods)22.