Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent hematopoietic stem cell (HSC) and the first human cancer that was found associated with a single consistent and causative molecular alteration, the oncogenic fusion tyrosine kinase BCR-ABL. This evidence concerns the gene BCR and chronic myelogenous leukemia, BCR-ABL1 positive.