By conducting middle cerebral artery occlusion (MCAO), Cai et al. proved that the concomitant application of a recombinant Tat-Ngb fusion protein in this model resulted in significantly (about one-third) less brain infarction volume, manifested in a better neurological outcome, if Tat-Ngb was injected intravenously 2 h before the reperfusion was initiated [91]. Here, NGB is linked to brain infarction.