For example, a nuclear repressor complex REST/CoREST/LSD1/HDAC was disrupted during the HSV-1 infection by ICP0, a viral gene transactivator that enhances downstream gene expression without any sequence specificity (for reviews, see [19, 20]), and then later in infection, CoREST and HDAC1 were translocated into the cytoplasm [21]. The gene discussed is RCOR1; the disease is infection.