Adjustment for potential confounders, including gender, age, history of fractures, history of osteopenia/osteoporosis, osteoporosis medication use, extent of pituitary insufficiency, ACTH insufficiency, LH/FSH insufficiency, pituitary surgery, radiotherapy and time between tumor treatment and start of GH replacement therapy did, not substantially influence the results (data not shown). This evidence concerns the gene GH1 and Osteopenia.