GH1 and hypopituitarism: Adjustment for potential confounders, including gender, age, history of fractures, history of osteopenia/osteoporosis, osteoporosis medication use, extent of pituitary insufficiency, ACTH insufficiency, LH/FSH insufficiency, pituitary surgery, radiotherapy and time between tumor treatment and start of GH replacement therapy did, not substantially influence the results (data not shown).