KRT88P and sickle cell disease: The HbC-dependent efflux of water from RBCs results in microcytosis and, due to an increased surface to volume ratio of the dehydrated erythrocytes, targeting on peripheral smear.1,2 The findings of microcytosis and targeting, both of which were documented early in the patient’s hospital course, can serve as diagnostic clues in favor of HbSC disease because neither is characteristically present in sickle cell trait, which lacks the HbC necessary to drive erthrocytic dehydration.