The mean serum level of IL-18 in patients with stage IV of LN (1007.86 ± 915.93 pg/ml) was significantly higher in comparison with stage II (192.95 ± 144.64 pg/ml) (P < 0.001), stage III (479.67 ± 151.39 pg/ml) (P < 0.001), stage V (765.54 ± 357.04 pg/ml) (P < 0.001) and stage VI (149.33 ± 163.09 pg/ml) (P < 0.001) (Figure 1). This evidence concerns the gene IL18 and lobular neoplasia.