FH and renal cell adenocarcinoma: There is variable expression in HLRCC, with one study reporting 87% of patients with FH mutations having skin leiomyomata, 96% of females having uterine leiomyomata (typically younger in age than those with sporadic tumors) (45), and 42% having RCC (46) – although a separate reviews put the risk of RCC between 15 and 20% (47).