Combination approaches that look at simultaneous or sequential use of immunotherapeutic approaches with agents that target the RAF/MEK/ERK pathway are also a priority, with evidence suggesting that targeted therapies can sensitize tumor cells to immune attacks and improve the effector function of immune cells, but it should not divert attention away from the pathway that induces such profound oncogene addiction in melanoma patients whose tumors contain activating mutations in BRAF. Here, BRAF is linked to melanoma.