NFKB1 and neoplasm: Activation of the NF-κB pathway does not only protect cells from apoptosis after treatment with various genotoxic agents via expression of anti-apoptotic proteins, such as Bcl-2, GADD45β, TRAF-1, TRAF-2, cIAP-1, and cIAP-2 (55), but also gives transformed cells a growth and survival advantage and further renders tumor cells therapy resistant (56).