ERBB2 and invasive breast carcinoma: The findings of the current study were, however, very similar to those of the HERA trial (Gianni et al. 2011), which reported 4-year OS rate of 89.3 % and RFS rate of 78.6 % among 1703 surgically-treated patients with HER2-positive early stage invasive breast cancer who were assigned to receive 1-year adjuvant trastuzumab after completion of ≥4 cycles of neoadjuvant and/or adjuvant chemotherapy.