In our experiment, we noted a significative increase of the glycemia, triglyceridemia, and cholesterolemia as well as a decrease of the insulinemia in animals submitted to hyperglucidic diet compared to corresponding controls signs of diabetes mellitus' installation, accompanied with an increase of atherogenic markers such as LDL-cholesterol, CPK, and LDH and with a decrease of cardioprotective lipid HDL-cholesterol. The gene discussed is PIK3C2A; the disease is diabetes mellitus.