HELZ2 and autoimmune disease: Recently, Fairfax B. reported that a known autoimmune disease locus, rs11171739 at 12q13.2 could trans-regulate the expression of PRIC285 (a well-known name for HELZ2) in B cells and suggested peroxisome proliferator-activated receptor γ (PPARG) signaling might be involved in autoimmune pathogenesis [20].