Previous GWAS had identified dozens of loci susceptible to primary biliary cirrhosis in European and Japanese population, such as HLA-DQB1, IL12A, IL12RB2, STAT4, SPIB, IRF5, IKZF3, IL7R, CD80, TNFSF15 and so on [16–19]. Here, IL12RB2 is linked to primary biliary cholangitis.