Compared to trastuzumab it has also less affinity for ACE; so the cause of observed hypertension by the use of bevacizumab may be due to destruction of microvessels or it may act as an agonist for ACE, whereas higher binding of trastuzumab to ACE may indicate the cause of infusion reaction by trastuzumab [5]. The gene discussed is ACE; the disease is hypertensive disorder.