DLC1 and neoplasm: To investigate the relationship between promoter hypermethylation and β-catenin subcellular localization, the number of gene promoters showing hypermethylation out of 7 (corresponding to the six genes examined, with two separate promoter regions, DLC1 and DLC1_i4, for DLC1) was calculated for each tumor and compared with nuclear versus membranous localization of β-catenin.