Some target genes associated with these loci were previously reported as putative tumor suppressor in colorectal cancer including MUC12 [40], MTUS1 [38], and ARFGAP1/SMAP1 [41], while others were novel targets with putative role in colorectal carcinogenesis that deserves further analysis (NFE2L3, DGKI, ADAMTSL1, RASSF8, DCTN2, GLIPR1, and ASGR1). The gene discussed is RASSF8; the disease is colorectal cancer.