Our data show that it is also a potential tumor suppressor in colorectal cancer and its expression is downregulated in association with β-catenin activity. DGKI (diacylglycerol kinase, iota) is a member of type IV diacylglycerol kinase subfamily which regulates the intracellular concentration of diacylglycerol through its phosphorylation. The gene discussed is DGKI; the disease is neoplasm.