MTOR and cardiac hypertrophy: The role of the 5′-AMP-activated protein kinase (AMPK)/mTORC1 pathway in the induction of autophagy in cardiac hypertrophy was reported by Li et al., who showed that AMPK stimulates autophagy by blocking the mTOR complex mTORC1 in a pressure overload model of cardiac hypertrophy (Li et al., 2014).