In fact, our results apparently contrast with recent investigations documenting the protection provided by 5-HT3 antagonists in TNBS-induced colitis in rats (Motavallian et al., 2013) and in 5-fluorouracil-induced intestinal mucositis in mice (Yasuda et al., 2013) and the controversial role, either protective or deleterious, described for 5-HT7 receptors in DSS-induced colitis (Kim et al., 2013; Guseva et al., 2014). Here, HTR3A is linked to colitis.