Although, the demonstration of a direct causal link between altered SNAP-25 expression and psychiatric diseases is still lacking, evidences obtained in the coloboma mouse suggest that reduction of SNAP-25 expression may be directly involved in some psychiatric traits, rather than simply represent an epiphenomenon; indeed, when a transgene expressing SNAP-25 was bred into the coloboma strain in order to complement Snap-25 depletion, the hyperactivity displayed by the mutant mice was rescued (Hess et al., 1995 J Neurosci). Here, SNAP25 is linked to coloboma.