SNAP25 and schizophrenia: Single nucleotide substitution resulting in a missense Ser187Ala mutation at the site of phosphorylation of SNAP-25 by PKC has been associated with increased anxiety, decreased dopamine and serotonine release (Kataoka et al., 2011), impaired PPI of the startle response, a typical parameter of schizophrenia, deficits in working memory, immature features of dentate granule cells (Ohira et al., 2013), and epileptic seizures (Watanabe et al., 2015).