It has been demonstrated that endoglin plays a role in many pathological processes, including cancer, angiogenesis, hereditary hemorrhagic telangiectasia (HHT), pre-eclampsia, pulmonary hypertension, heart failure, myocardial infarction, atrial fibrillation, atherosclerosis, and diabetes mellitus (Kapur et al., 2013[78]; Lee et al., 2012[92]; López-Novoa and Bernabeu, 2010[102]; Nachtigal et al., 2012[119]; Rosen et al., 2014[139]). Here, ENG is linked to hereditary hemorrhagic telangiectasia.