THPO and Splenomegaly: Several mechanisms have been suggested for thrombocytopenia in patients with liver disease, including increased platelet sequestration in the spleen as a result of congestive splenomegaly; reduced production of thrombopoietin by the liver; increased platelet breakdown due to auto-antibodies, and increased consumption resulting from low-grade disseminated intravascular coagulopathy (DIC) [5].