Intra-peritoneal injections of PO at 250 mg/kg body weight (daily for 28 days) has lead to increased serum concentration of creatinine, uric acid, BUN, and XO enzyme level(as indicator of impaired kidney function) along with deposition of urate crystals in renal parenchyma, atrophy of glomeruli and desquamation of tubular epithelium, severe congestion and hemorrhage with degeneration and necrosis of renal tubular epithelium and presence of proteinaceous cast in renal tubular lumen in rats of gout control group. This evidence concerns the gene XDH and gout.