UCA1 and colorectal carcinoma: In this study, we found that ectopic expression of UCA1 could promote the resistance of CRC cells to 5-FU by inhibiting 5-FU-induced apoptosis, whereas silencing UCA1 expression sensitized CRC cells to 5-FU by increasing apoptosis, suggesting that UCA1 may be a promising therapeutic target and predictive factor for the chemotherapy of CRC.