CREB1 and colorectal carcinoma: CREB1 knockdown phenocopied the proliferation-repressing and apoptosis-inducing effects of miR-204-5p, whereas anti-miR-204-5p could not restore these effects in CREB1-silenced CRC cells (Fig. 5d,e), indicating that CREB1 is a new functional target of miR-204-5p in CRC.