Recent studies have showed that UCA1 increased cisplatin resistance in bladder cancer and ovarian cancer22, 23 and may induce non-T790M-acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer, suggesting the important role of UCA1 in chemoresistance. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.