Macrophage-derived proinflammatory cytokines such as TNFα, IL-1, KC, or IL-6 activate the recruitment, phagocytosis, and killing of fungi, and mice deficient in these cytokines are more susceptible to systemic candidiasis (Basu and others 2008; Gorjestani and others 2012). The gene discussed is TNF; the disease is candidiasis.