VDAC1 and Alzheimer disease: In addition, Recent studies shown that Aβ interaction with mitochondrial and plasma membrane voltage-dependent anion channel 1 (VDAC1) is involved in the extrinsic apoptotic pathway, and VDAC1 is overexpressed in post-mortem brains of Alzheimer disease (AD) patients, suggest that VDAC1 may serve as a potential target for AD treatment [56–58].