IFNG and colitis: Indeed, C. rodentium infection induces a robust Th1/Th17 response with increased gene expression of IFN-γ, interleukin-12 (IL-12), IL-17, and IL-22 [38–39] while acute DSS colitis activates a predominant Th1 response but with upregulation of several Th2 cytokines including IL-10 [40].