TGF-β is a well-characterized, pro-fibrotic cytokine that activates HSCs, induces the latter’s expression of matrix-producing genes and inhibits degradation of ECM by downregulating MMP expression and promoting TIMP expression; this leads to the excessive deposition of collagen fibers and promotes liver fibrosis [17,18]. Here, TGFB1 is linked to Hepatic fibrosis.