HSP90B1 and polycystic ovary syndrome: Further analysis indicated that the PCOS cells with knocked down HSP90B1 had a reduced viability than the PCOS cells transfected with scramble siRNA (P<0.01), and the cell viability of normal ovarian cells with knocked down HSP90B1 also had a lower than the cells transfected with scramble siRNA, supporting the importance of HSP90B1 in ovarian cell survival (Fig 5B).